Diclazepam (Ro5-3448), otherwise called chlorodiazepam and 2′- chloro-diazepam, is a benzodiazepine and practical simple of diazepam. It was first orchestrated by Leo Sternbach and his group at Hoffman-La Roche in 1960. It isn’t right now affirmed for use as a prescription, yet rather sold as an unscheduled substance. Efficacy and security have not been tried in people.
In creature models, its belongings are like diazepam, having long-acting anxiolytic, anticonvulsant, entrancing, calming, skeletal muscle relaxant, and amnestic properties.
Digestion of this compound has been assessed, uncovering diclazepam has an inexact end half-existence of 42 hours and experiences N-demethylation to delorazepam, which can be distinguished in pee for 6 days following organization of the parent compound. Other metabolites recognized were lorazepam and lormetazepam which were discernible in pee for 19 and 11 days, separately, showing hydroxylation by cytochrome P450 chemicals happening simultaneously with N-demethylation.